Generalised cost-effectiveness analysis of 159 health interventions for the Ethiopian essential health service package

Abstract Background Cost effectiveness was a criterion used to revise Ethiopia’s essential health service package (EHSP) in 2019. However, there are few cost-effectiveness studies from Ethiopia or directly transferable evidence other low-income countries inform comprehensive revision of the Ethiopian EHSP. Therefore, this paper reports average ratios (ACERs) 159 interventions Methods In study, we estimate ACERs for 77 on reproductive maternal neonatal and child (RMNCH), infectious diseases water sanitation hygiene as well 82 non-communicable diseases. We standardised World Health Organization (WHO) CHOosing Interventions that cost effective methodology (CHOICE) generalised analysis. The benefits were determined using population state-transition model, which simulates population, accounting births, deaths disease epidemiology. Healthy life years (HLYs) gained employed measure benefits. estimated economic costs system perspective, including programme overhead training costs. Spectrum analysis tool data did not explicitly apply thresholds, but US$100 $1000 references summarise present ACER results. Results found ranging less than US$1 per HLY (for family planning) about US$48,000 treatment stage 4 colorectal cancer). general, 75% evaluated had US$1000 gained. vast majority (95%) RMNCH an while almost half (44%) greater HLY. Conclusion study shows several potential cost-effective available could substantially reduce burden if scaled up. use Organization’s allowed us rapidly calculate country-specific values under consideration